α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era.
Identifieur interne : 000138 ( Main/Exploration ); précédent : 000137; suivant : 000139α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era.
Auteurs : Naomi P. Visanji [Canada] ; Jonathan M. Brotchie [Canada] ; Lorraine V. Kalia [Canada] ; James B. Koprich [Canada] ; Anurag Tandon [Canada] ; Joel C. Watts [Canada] ; Anthony E. Lang [Canada]Source :
- Trends in neurosciences [ 1878-108X ] ; 2016.
Abstract
In recent years, a new generation of animal models of Parkinson's disease (PD) based on ectopic expression, overexpression, or intracerebral injection of the protein α-synuclein have emerged. Critically, these models develop inclusions of aggregated α-synuclein and/or α-synuclein-mediated neuronal loss replicating the defining pathological hallmarks of PD and driving significant advances in the understanding of the pathogenic mechanisms underpinning PD. Here, we provide a comprehensive review of this new generation of animal models of PD, ranging from invertebrate to rodent to nonhuman primate. We focus on their strengths and limitations with respect to their highly anticipated contribution to the further understanding of α-synuclein pathobiology and the future testing of novel disease-modifying therapeutics.
DOI: 10.1016/j.tins.2016.09.003
PubMed: 27776749
Affiliations:
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Brotchie</name><affiliation wicri:level="1"><nlm:affiliation>The Krembil Institute, University Health Network, Toronto, ONT, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Krembil Institute, University Health Network, Toronto, ONT</wicri:regionArea><wicri:noRegion>ONT</wicri:noRegion></affiliation></author><author><name sortKey="Kalia, Lorraine V" sort="Kalia, Lorraine V" uniqKey="Kalia L" first="Lorraine V" last="Kalia">Lorraine V. Kalia</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, Toronto, ONT, Canada; The Krembil Institute, University Health Network, Toronto, ONT, Canada; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ONT, Canada; Department of Medicine, University of Toronto, Toronto, ONT, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, Toronto, ONT, Canada; The Krembil Institute, University Health Network, Toronto, ONT, Canada; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ONT, Canada; Department of Medicine, University of Toronto, Toronto, ONT</wicri:regionArea><wicri:noRegion>ONT</wicri:noRegion></affiliation></author><author><name sortKey="Koprich, James B" sort="Koprich, James B" uniqKey="Koprich J" first="James B" last="Koprich">James B. 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Watts</name><affiliation wicri:level="4"><nlm:affiliation>Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ONT, Canada; Department of Biochemistry, University of Toronto, Toronto, ONT, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ONT, Canada; Department of Biochemistry, University of Toronto, Toronto, ONT</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, Toronto, ONT, Canada; The Krembil Institute, University Health Network, Toronto, ONT, Canada; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ONT, Canada; Department of Medicine, University of Toronto, Toronto, ONT, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, Toronto, ONT, Canada; The Krembil Institute, University Health Network, Toronto, ONT, Canada; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ONT, Canada; Department of Medicine, University of Toronto, Toronto, ONT</wicri:regionArea><wicri:noRegion>ONT</wicri:noRegion></affiliation></author></analytic><series><title level="j">Trends in neurosciences</title><idno type="eISSN">1878-108X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In recent years, a new generation of animal models of Parkinson's disease (PD) based on ectopic expression, overexpression, or intracerebral injection of the protein α-synuclein have emerged. Critically, these models develop inclusions of aggregated α-synuclein and/or α-synuclein-mediated neuronal loss replicating the defining pathological hallmarks of PD and driving significant advances in the understanding of the pathogenic mechanisms underpinning PD. Here, we provide a comprehensive review of this new generation of animal models of PD, ranging from invertebrate to rodent to nonhuman primate. We focus on their strengths and limitations with respect to their highly anticipated contribution to the further understanding of α-synuclein pathobiology and the future testing of novel disease-modifying therapeutics.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Visanji, Naomi P" sort="Visanji, Naomi P" uniqKey="Visanji N" first="Naomi P" last="Visanji">Naomi P. Visanji</name></noRegion><name sortKey="Brotchie, Jonathan M" sort="Brotchie, Jonathan M" uniqKey="Brotchie J" first="Jonathan M" last="Brotchie">Jonathan M. Brotchie</name><name sortKey="Kalia, Lorraine V" sort="Kalia, Lorraine V" uniqKey="Kalia L" first="Lorraine V" last="Kalia">Lorraine V. Kalia</name><name sortKey="Koprich, James B" sort="Koprich, James B" uniqKey="Koprich J" first="James B" last="Koprich">James B. Koprich</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><name sortKey="Tandon, Anurag" sort="Tandon, Anurag" uniqKey="Tandon A" first="Anurag" last="Tandon">Anurag Tandon</name><name sortKey="Watts, Joel C" sort="Watts, Joel C" uniqKey="Watts J" first="Joel C" last="Watts">Joel C. Watts</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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